Big Board Alerts

Campaign to raise research investment into anti-seizure medication for pregnant women

The Epilepsy Research Institute is supporting a campaign launched by the Epilepsy Society at the House of Lords, calling for a £20million investment in research into anti-seizure medication for pregnant women. The knowledge of risks associated with sodium valproate has accumulated slowly over time and has been underpinned by the significant investment made by the Epilepsy Research Institute.

Valproate carries a 10% risk of major malformations and a 30-40% risk of developmental symptoms. The decline in prescribing the drug to expectant women occurred after decades of use, where countless babies were born with preventable causes of physical and learning disabilities.

Certain anti-seizure medications cause neurodevelopmental symptoms and malformations in babies when they are exposed in utero. But it is not understood the mechanisms by which these harms occur or how to mitigate them. Nor the potential for risk posed to children fathered by men taking anti-seizure medications, or if there are transgenerational effects.

Reproduction & Hormones is one of four key strategic themes of the Epilepsy Research Institute and is in direct response to the priorities of people affected by epilepsy, as evidenced in the UK Epilepsy Priority Setting Partnership we funded and led in 2021/22. Each theme lead is supported by a task force group of leading UK scientists and clinicians. The research themes are driving a programme to secure large-scale research investment which will feed into an overall roadmap for research into epilepsy.

Through the Reproduction & Hormones programme theme, the Institute will enable those living with epilepsy to make fully informed decisions on their treatment, but also have options for treatments that will not cause any congenital malformations or cognitive impairments.

Professor Tony Marson, Programme Director at the Epilepsy Research Institute said: It is vital that we work collaboratively across the UK and with international partners to undertake and deliver the research that will enable minimising risk to both people with epilepsy and their children. That will include providing reliable estimates of risks, and a better understanding of women and men’s preferences to inform risk benefit considerations and treatment decisions.”

Dr Rebecca Bromley, Reproduction & Hormones Theme Lead at the Epilepsy Research Institute said: Enhancing the UK research landscape on this topic is critical if we are going to reduce the latencies we currently experience between the onset of a medications use and comprehensive data regarding its risk and safety profile.”

Maxine Smeaton, Chief Executive at the Epilepsy Research Institute said: Key to achieving better outcomes for women and their babies, is the imperative to drive multicentre, multidisciplinary approach to research. The Epilepsy Research Institute is central to convening and coordinating both a national and global initiative on this work.”

 

Latest Articles

DON’T MISS THE OPPORTUNITY TO JOIN OUR MARKET SUMMARY REPORT FOR A LIMITED TIME

By submitting this form on our website, you agree that we may collect and use your personal information for marketing, and for other purposes as set forth in our privacy policy, which we encourage you to review.